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A cocaine vaccine is in early testing stage. The hope of this vaccine is to reduce the risk of relapse and the return to cocaine use. The vaccine works by stimulating the production of cocaine-specific antibodies. These antibodies bind to cocaine, preventing it from crossing the blood-brain barrier and stimulating the pleasure center. So far, studies in humans have shown mixed results. Some patients with high levels of antibodies were better in abstaining from cocaine. However, other studies showed no difference in ability to abstain between those with higher levels of antibodies versus those who received a placebo vaccine.

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