If, after step 4, the FRIO needs additional soaking because it is too soft, re-place it in the water for about one minute. Repeat steps 3 and 4 as necessary. Never force your medication or pump into the wallet. If you need to force the medication or pump in, you have over-soaked the wallet. If this occurs, follow the directions for drying out the wallet. When the crystals evaporate sufficiently, you will be able to fit your medication or pump inside.
3. Gently spread the crystals evenly through the pouch. The gel formed should fill the panels but should not expand to the point where the panels become rigid. The activated pouch should remain pliable.
Crystal Cold Manual
The FRIO inner pouch should be re-immersed in water when the quantity of gel reduces and gel starts to return to its crystal form, i.e. crystals can be felt in the panels. When in continuous use, succeeding immersion periods will be shorter, i.e. 3-4 minutes, as the crystals are always in gel form. It is extremely important that the correct amount of water is absorbed during immersion because over-soaking causes the wallet to become too swollen to be used! Should this occur, the wallet must be allowed to dry naturally until it returns to a usable size.
Storage Instructions When not in use, remove the inner pouch from the outer cover and allow it to completely dry out naturally until the gel returns to crystal form. To keep the crystals separate, give the pouch an occasional shake whilst drying out. When completely dry, your FRIO should be stored in dry conditions until next required. The drying out period can take 2-4 weeks depending on the environmental climate.
Cleaning Instructions The outer cover of the wallet can be washed in warm water using a very mild detergent. The inner wallet can be spot cleaned by using a soft bristle brush. Dip the brush into slightly soapy water and spot clean the wallet. You can then rinse the wallet under running water without damaging the crystals inside. Alternatively, you can use a non-bleach anti-bacterial cleaning spray or an anti-bacterial kitchen or baby wipe to clean your wallet.
These instructions are only a guide. Due to varied climatic and environmental conditions, FRIO wallets will respond differently according to location. If activated and used sensibly, they will continue to respond to your needs over a long period of time. With age, the length of immersion time will increase. However, as long as the crystals expand into a gel, the wallet will function properly. When the crystals fail to expand, the wallet will need to be replaced.
IMPORTANT: This manual includes important safety material; please read all instructions before plugging the power supply cord into the receptacle.if(typeof ez_ad_units!='undefined')ez_ad_units.push([[336,280],'manuals_plus-large-mobile-banner-1','ezslot_2',115,'0','0']);__ez_fad_position('div-gpt-ad-manuals_plus-large-mobile-banner-1-0');STOP & READ DIRECTIONS before plugging in the dispenser.Read the complete HOW TO INSTALL instruction sequence before plugging in and turning on the dispenser. Failure to follow proper installation instructions may cause damage to the water dispenser.Contents hide1SAFETY PRECAUTIONS2CLEANING AND SANITIZING3TROUBLESHOOTING4Documents / ResourcesSAFETY PRECAUTIONSBasic safety precautions should be followed when using electrical appliances, including:
1. Turn off the hot tank heater switch on the back of the dispenser and unplug your unit (Fig 1). Let the unit stand for one hour before cleaning to allow the hot tank to cool. (NOTE: If your cooler does not dispense hot water, you can proceed immediately to Step 2.)2. Remove the water bottle and drain the water reservoir by dispensing water through the hot and cold spigots.3. Clean the cabinet, bottle receptacle, and spigots with 70% rubbing alcohol or disinfecting wipes. Vacuum or wipe the grill on the back of the dispenser to remove any dust.
WARNING: Dispense water through the hot and cold spigots before plugging in and turning on the hot tank switch. Failure to follow proper installation instructions may cause damage to the water dispenser.TROUBLESHOOTINGWARNING: Always turn off the dispenser and unplug from the power outlet before inspecting or starting any maintenance.WATER IS LEAKINGThe no-spill bottle was loaded with the cap removed.The bottle may have a puncture or crack. Remove and install the new bottle.WATER DOES NOT FLOW FROM THE DISPENSER
Gout is a disorder in which deposits of uric acid crystals accumulate in the joints because of high blood levels of uric acid (hyperuricemia). The accumulations of crystals cause flares (attacks) of painful inflammation in and around joints.
Most often, the uric acid level in the blood becomes abnormally high when the kidneys cannot eliminate enough uric acid in the urine, even if kidney function is otherwise normal. This cause is usually determined by the person's genes. Too much uric acid in the blood can result in uric acid crystals being formed and deposited in and around joints.
High levels of uric acid in the blood often lead to high levels of uric acid in the joints. This process may then result in the formation of uric acid crystals in the joint tissue and the fluid within the joints, called synovial fluid.
Gout most often affects the joints in the feet, particularly at the base of the big toe. Swelling, pain, and redness of the big toe due to gout is called podagra. However, gout also commonly affects other areas: the ankle, instep, knee, wrist, and elbow. Gout tends to affect these cooler areas because uric acid crystals form more readily in cool than in warm areas. Rarely, gout affects the joints of the warmer, central part of the body, such as the spine, hips, or shoulders.
Hard lumps of uric acid crystals (tophi) are first deposited in the joint (synovial) lining or cartilage or in bone near the joints and then under the skin around joints. Tophi can also develop in the kidney and other organs and under the skin on the ears. They commonly develop in the fingers, hands, feet, the Achilles tendon in the back of the lower leg, or around the elbows.
If untreated, tophi in and around the joints can burst and discharge chalky masses of uric acid crystals through the skin and may eventually cause deformities and osteoarthritis Osteoarthritis (OA) Osteoarthritis is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Arthritis due to damage of joint... read more .
The diagnosis of gout is usually confirmed when uric acid crystals are identified in a sample of a tophus or in joint fluid removed with a needle (joint aspiration Joint aspiration (arthrocentesis) A doctor can often diagnose a musculoskeletal disorder based on the history and the results of a physical examination. Laboratory tests, imaging tests, or other diagnostic procedures are sometimes... read more ) and viewed under a special microscope with polarized light.
Preventive daily drug treatment may be needed for people who experience repeated, severe flares. Colchicine may be taken daily to prevent flares or to greatly reduce their frequency. NSAIDs taken daily can also prevent flares. These medications help prevent crystals from causing the inflammation that results in flares. However, colchicine and NSAIDs may cause some side effects and do not prevent excess deposits of uric acid in and around joints.
People with gout who take a diuretic to treat high blood pressure Treatment High blood pressure (hypertension) is persistently high pressure in the arteries. Often no cause for high blood pressure can be identified, but sometimes it occurs as a result of an underlying... read more may have fewer flares if they take losartan or a similar medication rather than a diuretic to control their blood pressure. However, preventing flares by switching from a diuretic to losartan or another drug to treat high blood pressure does not prevent or heal existing joint damage caused by uric acid crystals because the crystals are still in the joints between flares of gout. Also, these alternative medications may have side effects. Most importantly, diuretics may be necessary to control blood pressure and prevent strokes or heart attacks.
Allopurinol is most often used to lower the blood level of uric acid. This medication blocks the production of uric acid in the body. However, allopurinol can upset the stomach and can sometimes cause a rash, decrease the number of white blood cells, or cause liver damage or inflammation of vessels (vasculitis Overview of Vasculitis Vasculitic disorders are caused by inflammation of the blood vessels (vasculitis). Vasculitis can be triggered by certain infections or drugs or can occur for unknown reasons. People may have... read more ). Allopurinol, like all uric acid lowering drugs, can trigger acute flares when it is first taken (mobilization flare Mobilization flares Gout is a disorder in which deposits of uric acid crystals accumulate in the joints because of high blood levels of uric acid (hyperuricemia). The accumulations of crystals cause flares (attacks)... read more ). Because low-dose colchicine or an NSAID can decrease this risk, one of these drugs is usually given at the time allopurinol (or febuxostat) is started and continued for about 6 months or longer if flares continue or tophi are present.
A sporulating culture ofBacillus thuringiensis subsp.kenyae strain HD549 is toxic to larvae of lepidopteran insect species such asSpodoptera litura, Helicoverpa armigera andPhthorimaea operculella, and a dipteran insect,Culex fatigans. A 1.9-kb DNA fragment, PCR-amplified from HD549 using cryII-gene-specific primers, was cloned and expressed inE. coli. The recombinant protein produced 92% mortality in first-instar larvae ofSpodoptera litura and 86% inhibition of adult emergence inPhthorimaea operculella, but showed very low toxicity againstHelicoverpa armigera, and lower mortality against third-instar larvae of dipteran insectsCulex fatigans, Anopheles stephensi andAedes aegypti. The sequence of the cloned crystal protein gene showed almost complete homology with a mosquitocidal toxin gene fromBacillus thuringiensis var.kurstaki, with only five mutations scattered in different regions. Amino acid alignment with different insecticidal crystal proteins using the MUTALIN program suggested presence of the conserved block 3 region in the sequence of this protein. A mutation in codon 409 of this gene that changes a highly conserved phenylalanine residue to serine lies in this block. 2ff7e9595c
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